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XBI

ETF

STATE STREET(R) SPDR(R) S&P(R) BIOTECH ETF

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$151.20
-$5.11 (3.27%)
At close: Nov 12, 2026, 4:00 PM

Description

The SPDR S&P Biotech ETF (XBI) invests primarily in U.S. biotechnology and pharmaceutical companies, holding a broad basket of small‑ and mid‑cap stocks that develop drugs, diagnostics, and related technologies. Its strategy follows an equal‑weight approach to the S&P Biotechnology Select Industry Index, regularly rebalancing to maintain balanced exposure across the sector rather than concentrating on the largest firms. The fund is suited to investors who want targeted, diversified exposure to the biotech industry and are comfortable with the higher volatility and growth orientation typical of this sector.

Top Holdings

The largest holdings of XBI by portfolio weight.

SymbolNameWeight
MRNAMODERNA INC2.27%
TWSTTWIST BIOSCIENCE CORP1.99%
NTRANATERA INC1.85%
HALOHALOZYME THERAPEUTICS INC1.74%
BIIBBIOGEN INC1.67%
AMGNAMGEN INC1.66%
UTHRUNITED THERAPEUTICS CORP1.66%
SYRESPYRE THERAPEUTICS INC1.65%
ABBVABBVIE INC1.64%
EXELEXELIXIS INC1.63%
IOVAIOVANCE BIOTHERAPEUTICS INC1.62%
GILDGILEAD SCIENCES INC1.57%
GRALGRAIL INC1.51%
ORKAORUKA THERAPEUTICS INC1.51%
TGTXTG THERAPEUTICS INC1.51%
VRTXVERTEX PHARMACEUTICALS INC1.46%
REGNREGENERON PHARMACEUTICALS INC1.45%
CRSPCRISPR THERAPEUTICS AG1.43%
ALKSALKERMES PLC1.43%
PTGXPROTAGONIST THERAPEUTICS INC1.40%

Explore every XBI holding

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